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M9460267.TXT
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1994-06-12
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Document 0267
DOCN M9460267
TI Risk factors for anal human papillomavirus infection and anal cytologic
abnormalities in HIV-positive and HIV-negative homosexual men.
DT 9408
AU Palefsky JM; Shiboski S; Moss A; Department of Laboratory Medicine,
University of California, San; Francisco 94143.
SO J Acquir Immune Defic Syndr. 1994 Jun;7(6):599-606. Unique Identifier :
AIDSLINE MED/94231465
AB Men with advanced human immunodeficiency virus (HIV) disease have a high
prevalence of anal human papillomavirus (HPV) infection and potentially
precancerous anal disease. To characterize prevalence of and risk
factors for anal HPV infection and anal cytologic abnormalities, 37
HIV-positive and 28 HIV-negative participants in the San Francisco
General Hospital Cohort Study were studied. A questionnaire was
administered, followed by an anal examination consisting of two
consecutive anal swabs for cytology and HPV DNA hybridization, and
anoscopy with biopsy of visible lesions. Ten of 28 (36%) HIV-negative
men and 19 of 37 (51%) HIV-positive men had anal HPV infection (p =
0.32). Risk factors for anal HPV infection included HIV positivity with
a CD4 count < 200/mm3 (p = 0.03) and a history of smoking (p = 0.03).
Abnormal anal cytology was found in 2 of 26 (8%) HIV-negative men and 10
of 36 (28%) HIV-positive men with cytology adequate for interpretation
(p = 0.09). Risk factors for abnormal anal cytology included HIV
positivity with a CD4 count < 200/mm3 (p = 0.006) and current smoking (p
= 0.03). We conclude that the risk of development of anal disease and
HPV infection was highest among HIV-positive men with a CD4 count of <
200/mm3, and that smoking may play a role in the pathogenesis of anal
disease.
DE Adult Analysis of Variance Anus/*PATHOLOGY Cohort Studies DNA
Probes, HPV *Homosexuality Human HIV Seropositivity/*COMPLICATIONS
Male Multivariate Analysis Odds Ratio *Papillomavirus, Human
Papovaviridae Infections/EPIDEMIOLOGY/*ETIOLOGY Prevalence Prospective
Studies Risk Factors Smoking/ADVERSE EFFECTS Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. Tumor Virus
Infections/EPIDEMIOLOGY/*ETIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).